Are you using Supercritical Fluid Chromatography (SFC) to Separate Basic Compounds?
Have you tried GreenSep 4-Ethyl Pyridine? SFC without basic modifiers!
GreenSep 4-Ethyl Pyridine is an alternative to and provides different selectivity when compared to GreenSep Ethyl Pyridine (2-Ethyl Pyridine).
The type of chemicals separated on the GreenSep 4-Ethyl Pyridine columns would normally require the addition of an amine to the mobile phase; however, GreenSep 4-Ethyl Pyridine does not require the addition of these peak shape modifiers. Mobile phase composition and fraction collection is greatly simplified without the use of amino additives
Then try a GreenSep 4-Ethyl Pyridine Column now …