GreenSep FluoroBasic is based on fluorinated imidazole chemistry providing a highly basic and fluorinated character for this stationary phase. The addition of a fluorine groups into this stationary phase can be useful in promoting fluorophilic retention mechanism which can provide improved retention for fluorinated compounds. A fluorophilic retention mechanism can be particular useful in medicinal chemistry and drug discovery, where more than a third of newly approved small molecule drugs contain fluorine.
The column ideally suited for the retention and rapid separation of chemicals containing acidic groups. Chemicals that contain acidic groups and demonstrate the retention and separation capability that GreenSep Ethyl Pyridine II can deliver for the SFC chromatographer.
GreenSep NP-II is the product of ES Industries column research efforts to develop products that are specifically designed to tackle the separation of complex natural product samples. GreenSep NP-II has been specifically optimized for the separation and isolation of THC and THCV from cannabis.
GreenSep Amino Phenyl is a specialty SFC stationary phase that has proven superior to conventional stationary phases in the areas of separation selectivity and loading capacity which was designed for the separation of amines, alcohols and acids by SFC without the use of additives. Works well in Normal Phase mixed mode offering pi-pi interaction and exhibits good base deactivation.
A specialty phase designed for SFC with a high density Diol surface coverage which ensures separations better and more reproducible than conventional unbonded silica. GreenSep Diol is particularly suitable for acidic and basic analytes.
GreenSep Basic exhibits a highly basic character and is ideally suited to high performance/high speed SFC preparative chromatography applications of chemicals containing amine groups. The chromatogram shown below contains chemicals that are functionalized with amine and acidic groups and is a prime example of the superior peak shape performance and separation capacity obtainable with the GreenSep Basic column. It also compares GreenSep Basic with GreenSep Ethyl Pyridine showing the superior reten- tion on GreenSep Basic when compared to GreenSep Ethyl Pyridine.