Epic HILIC-FL is useful for retention and separation of polar and non-compounds. Reversed-phase HPLC is widely used for separation of many pharmaceutical compounds. However, retention and separation of many polar analytes has proven to be a challenge. Many of these types of compounds are unretained or poorly retained on most conventional reversed-phase stationary phases, such as ODS. Fortunately, to deal with these types of analytes an alternative mode of chromatography can be utilized using polar stationary phases and highly organic mobile phases. This mode of chromatography has been utilized for many years and is referred to as “hydrophilic interaction chromatography” or HILIC. HILIC chromatography uses mobile phases containing between 5 – 20 % water for the retention of polar compounds.
Epic C18 is a highly base deactivated phase that produces the most inert silica C18 material available today. Because of the high density bonding levels (4umol/m2) this column demonstrates superior peak shapes for the most demanding tests. Epic C18 provides exceptional peak shape and selectivity over a wide pH range (pH 1-12).
Epic C18 MSO (mass spec optimized) is specifically engineered for the demands of LC-MS with or without the use of ultra-high pressure pumps. The flexibility of Epic C18-MSO is the result of our research into optimal particle diameters that can be used for both routine and ultra-high pressure pumping systems. Epic C18-MSO is based upon 2.3um fully porous particles giving it superior retention even at high organic levels while maintaining excellent sample loading.
Epic C18 MS 1.8 um is specifically engineered for the demands of LC-MS. It provides superior retention even at high organic levels. Many LC-MS applications rely on high level of organic modifier in the mobile phase, particularly in the for high performance trace analysis requiring high sensitivity and low level detection
Epic Biphenyl is a truly unique stationary phase with properties significantly different than ODS phases. This unique character results from bonded biphenyl group imparting a pi-pi electron interaction which produces an enhanced retention for many compounds particularly those that contain polarizable electrons. Many classes of compounds contain polarizable electrons including halogenated compounds, aromatics, nitro aromatics and conjugated systems.