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Epic Diphenyl bonded phase, with reduced hydrophobicity produces HPLC columns with novel selectivity, exhibiting increased speed and resolution, utilizes strong dipole‐dipole hydrogen bonding and π‐π mechanisms for different selectivity for compounds containing double bonds or aromatic functional groups. In addition, the diphenyl arrangement of the phase can also contribute to steric selectivity allowing for an additional chromatographic interaction. Epic Diphenyl is also highly selective for proteins with aromatic side chains and may be used as a USP L11 column.
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