Epic C18 SD sub-2 micron is specifically engineered for the demands of high performance HPLC. Epic C18-SD is a product of high bonding density technology; high bonding density provides the maximum stationary phase interaction providing a platform for flexible mobile phase compositions. It provides superior retention even at low and especially at high organic levels. In addition, it is compatible with all LC-MS mobile phases and buffer systems.
Epic C18 is a highly base deactivated phase that produces the most inert silica C18 material available today. Because of the high density bonding levels (4umol/m2) this column demonstrates superior peak shapes for the most demanding tests. Epic C18 provides exceptional peak shape and selectivity over a wide pH range (pH 1-12).
Epic HILIC-FL is useful for retention and separation of polar and non-compounds. Reversed-phase HPLC is widely used for separation of many pharmaceutical compounds. However, retention and separation of many polar analytes has proven to be a challenge. Many of these types of compounds are unretained or poorly retained on most conventional reversed-phase stationary phases, such as ODS. Fortunately, to deal with these types of analytes an alternative mode of chromatography can be utilized using polar stationary phases and highly organic mobile phases. This mode of chromatography has been utilized for many years and is referred to as “hydrophilic interaction chromatography” or HILIC. HILIC chromatography uses mobile phases containing between 5 – 20 % water for the retention of polar compounds.
Epic Diphenyl bonded phase, with reduced hydrophobicity produces HPLC columns with novel selectivity, exhibiting increased speed and resolution, utilizes strong dipole‐dipole hydrogen bonding and π‐π mechanisms for different selectivity for compounds containing double bonds or aromatic functional groups. In addition, the diphenyl arrangement of the phase can also contribute to steric selectivity allowing for an additional chromatographic interaction. Epic Diphenyl is also highly selective for proteins with aromatic side chains and may be used as a USP L11 column.