MacroSep BIO Gold HPR significantly reduces the hydrophobic interaction of the stationary phase. This reduced interaction can yield less retention of hydrophobic biological molecules yielding better recoveries and quicker separations. HPR is the most hydrophilic of the MacroSep BIO Gold phases and may be useful for fluorine modified biologics based upon a fluorophilicity interaction. MacroSep BIO Gold columns are manufactured utilizing tight process control of the silica, bonding and column packing processes. The reproducible column packing method control provides exceptional efficiency, symmetry and reproducibility. There are eight phases (see below) all available in 1.9μm, 3μm, 5μm and 10μm particle sizes. The 10μm material is available in bulk.