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MacroDac™ C4 is an excellent alternative to W.R. Grace VYDAC® wide pore C4 chromatography media. MacroDac™ C4 is the ideal medium for high-performance reversed-phase chromatography of proteins, peptides, and other large molecules that had previously been difficult to separate by reversed-phase HPLC procedures. The large pores of the 300Å silica allow polypeptide molecules complete access to the interior of the silica pores. MacroDac™ C4 reversed-phase material consists of butyl aliphatic groups bonded to the surface of 300Å pore diameter silica. The unique process by which we manufacture MacroDac™ C4 provides for an HPLC media with very high purity synthetic silica and carefully controlled characteristics. The hydrophobic (reversed) phase is attached to the silica using polyfunctional butylchlorosilanes resulting in cross-linking, or polymerization of the hydrophobic phase.
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