MacroSepTM BIO-Gold packings are based on ultra-high purity spherical silica, state-of-the-art high density bonding and full endcapping produces the separation or purification of high molecular weight bio compounds such as proteins and peptides.

MacroSep BIO-Gold BiPhenyl

MacroSep BIO Gold Biphenyl – very good bonding density, less hydrophobic than the Naphthyl and provides excellent pi-pi interactions. Used to separate bio-pharmaceuticals and biologicals. MacroSep BIO Gold columns are manufactured utilizing tight process control of the silica, bonding and column packing processes. The reproducible column packing method control provides exceptional efficiency, symmetry and reproducibility. There are eight phases (see below) all available in 1.9μm, 3μm, 5μm and 10μm particle sizes. The 10μm material is available in bulk.

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MacroSep BIO-Gold C18

MacroSep BIO Gold C18 – a hydrophobic phase ideal for the separation of high molecular weight peptides and oligonucleic acids. MacroSep BIO Gold columns are manufactured utilizing tight process control of the silica, bonding and column packing processes. The reproducible column packing method control provides exceptional efficiency, symmetry and reproducibility. There are eight phases (see below) all available in 1.9μm, 3μm, 5μm and 10μm particle sizes. The 10μm material is available in bulk.

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MacroSep BIO-Gold C4

MacroSep BIO Gold C4 – least hydrophobic of all the alkyl MacroSep BIO phases (ODS & C8) and may be used for hydrophilic proteins and BIO-polymers. MacroSep BIO Gold columns are manufactured utilizing tight process control of the silica, bonding and column packing processes. The reproducible column packing method control provides exceptional efficiency, symmetry and reproducibility. There are eight phases (see below) all available in 1.9μm, 3μm, 5μm and 10μm particle sizes. The 10μm material is available in bulk.

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MacroSep BIO-Gold C8

MacroSep BIO Gold C8 – less hydrophobic and may yield faster separations when compared to C18 and is used to separate many classes of compounds including bio-pharmaceuticals and biologicals. MacroSep BIO Gold columns are manufactured utilizing tight process control of the silica, bonding and column packing processes. The reproducible column packing method control provides exceptional efficiency, symmetry and reproducibility. There are eight phases (see below) all available in 1.9μm, 3μm, 5μm and 10μm particle sizes. The 10μm material is available in bulk.

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MacroSep BIO-Gold DiPhenyl

MacroSep BIO Gold Diphenyl – the lowest bonding density and one of the lowest hydrophobicities of any BIO Gold Phenyl phases. Provides some site specific phenyl interactions dependant on the molecular configuration of the target. Resolves many classes of proteins and bio-polymers. MacroSep BIO Gold columns are manufactured utilizing tight process control of the silica, bonding and column packing processes. The reproducible column packing method control provides exceptional efficiency, symmetry and reproducibility. There are eight phases (see below) all available in 1.9μm, 3μm, 5μm and 10μm particle sizes. The 10μm material is available in bulk.

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MacroSep BIO-Gold HPR

MacroSep BIO Gold HPR significantly reduces the hydrophobic interaction of the stationary phase. This reduced interaction can yield less retention of hydrophobic biological molecules yielding better recoveries and quicker separations. HPR is the most hydrophilic of the MacroSep BIO Gold phases and may be useful for fluorine modified biologics based upon a fluorophilicity interaction. MacroSep BIO Gold columns are manufactured utilizing tight process control of the silica, bonding and column packing processes. The reproducible column packing method control provides exceptional efficiency, symmetry and reproducibility. There are eight phases (see below) all available in 1.9μm, 3μm, 5μm and 10μm particle sizes. The 10μm material is available in bulk.

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MacroSep BIO-Gold Naphthyl

MacroSep BIO Gold Naphthyl – highest bonding density resulting in an inert and stable phase, very high hydrophobicity and a significant pi-pi interaction. Ideal for the separation of high MW peptides and oligonucleic acids. MacroSep BIO Gold columns are manufactured utilizing tight process control of the silica, bonding and column packing processes. The reproducible column packing method control provides exceptional efficiency, symmetry and reproducibility. There are eight phases (see below) all available in 1.9μm, 3μm, 5μm and 10μm particle sizes. The 10μm material is available in bulk.

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MacroSep BIO-Gold PFP

MacroSep BIO Gold PFP – strongest pi-pi interaction of all the BIO Gold phases. The most hydrophilic of the BIOGold phenyl phases and may be used for fluorine modified biologics based upon a fluorophilicity interaction. MacroSep BIO Gold columns are manufactured utilizing tight process control of the silica, bonding and column packing processes. The reproducible column packing method control provides exceptional efficiency, symmetry and reproducibility. There are eight phases (see below) all available in 1.9μm, 3μm, 5μm and 10μm particle sizes. The 10μm material is available in bulk.

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