ChromegaChiral CCA

ChromegaChiral CCA F4 – The addition of a fluorine atom into a phenyl carbamate amylose structure can be useful in promoting fluorophilic retention mechanism which can provide improved retention for fluorinated compounds (1). A fluorophilic retention mechanism can be particularly useful in medicinal chemistry and drug discovery, where more than a third of newly approved small molecule drugs contain fluorine (2). ChromegaChiral CCA-F4 is an 4-Fluoro 3-methylphenyl amylose phase which can be used in SFC or HPLC.

A polysaccharide coated chiral stationary phase and columns which are produced using a unique production process of coating the proven chiral selector, tris-(3,5-di- methylphenyl) carbamoyl amylose on high purity silica gel. ChromegaChiral CCA columns, similar in selectivity to ChiralPak® AD, are available in 3, 5, 10, and 20 micron particle sizes enabling easy scale up from analytical to preparative scale using HPLC or SFC conditions.