ChromegaChiral CCO F4

ChromegaChiral CCO F4 – The addition of a fluorine atom into a phenyl carbamate cellulose structure can be useful in promoting fluorophilic retention mechanism which can provide improved retention for fluorinated compounds (1). A fluorophilic retention mechanism can be particularly useful in medicinal chemistry and drug discovery, where more than a third of newly approved small molecule drugs contain fluorine (2). ChromegaChiral CCO-F4 is an 4-Fluoro 3-methylphenyl cellulose phase which can be used in SFC or HPLC.

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ChromegaChiral CCO F4 T3

ChromegaChiral CCO F4 T3 (4-Fluoro-3-(trifluoromethyl) phenyl cellulose) incorporates fluoro groups into its structure. The addition of a fluorine atom into a phenyl cellulose structure can be useful in promoting fluorophilic retention mechanism which can provide improved retention for fluorinated compounds (1). A fluorophilic retention mechanism can be particular useful in medicinal chemistry and drug discovery, where more than a third of newly approved small molecule drugs contain fluorine (2). ChromegaChiral CCO-F4T3 is 4-Fluoro-3-(trifluoromethyl) phenyl cellulose phase can be used in SFC or HPLC.

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ChromegaChiral CCS

ChromegaChiral CCS (amylose tris [(S)-α-methylbenzylcarbamate]) permits the enantiomeric separation of 1-Indanol without the addition of DEA (Diethyl amine). Historically DEA has been commonly used to improve peak shape for chiral separations of compounds such as 1-Indanol. ChromegaChiral CCS separates the 1-Indanol enantiomers with sharp peaks without DEA, providing superior chiral separations, sample loading and peak shape performance. Similar in selectivity to ChiralPak® AS-H.

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ChromegaChiral CCU

ChromegaChiral CCU is a modified amylose coated on high purity, high performance spherical silica particles. The chemical modification includes the combination of chemical bonding groups of methylbenzylcarbamate and 3-chloro-4 methylphenylcarbamate attached to amylose. This combination of bonded groups stabilizes the solubility of coated phase making for a durable phase similar to other widely used coated phases. The use of amylose modified with phenyl groups provides for the separation for many previously unresolved/poorly resolved chiral mixtures.

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ChromegaChiral CCX

ChromegaChiral CCX is a modified amylose coated on the high purity, high performance spherical silica particles. The chemical modification includes the combination of chemical bonding groups of methylbenzylcarbamate and 3,5-dimetheylphenylcarbamate attached to amylose. This combination of bonded groups stabilizes the solubility of coated phase making for a durable phase similar to other widely used coated phases. The use of amylose modified with phenyl groups provides for the separation for many previously unresolved/poorly resolved chiral mixtures.

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Chromegasphere SI100

Chromegasphere SI100 Silica HPLC columns are manufactured from metal free ultra-high purity synthetic silica. TLC solvent systems translate directly to the Chromegasphere SI100 Silica HPLC columns and the high loading capacities permit preparative scale separations.

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Epic Amine HD

The Epic bonding technology produces columns of superior performance and durability. These performance characteristics result from the high bonding density found in the Epic bonding process.

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Epic Biphenyl

Epic Biphenyl is a truly unique stationary phase with properties significantly different than ODS phases. This unique character results from bonded biphenyl group imparting a pi-pi electron interaction which produces an enhanced retention for many compounds particularly those that contain polarizable electrons. Many classes of compounds contain polarizable electrons including halogenated compounds, aromatics, nitro aromatics and conjugated systems.

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Epic C12

The Epic bonding technology produces columns of superior performance and durability. These performance characteristics result from the high bonding density found in the Epic bonding process.

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Epic C18

Epic C18 is a highly base deactivated phase that produces the most inert silica C18 material available today. Because of the high density bonding levels (4umol/m2) this column demonstrates superior peak shapes for the most demanding tests. Epic C18 provides exceptional peak shape and selectivity over a wide pH range (pH 1-12).

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Epic C18 MS

Epic C18 MS 1.8 um is specifically engineered for the demands of LC-MS. It provides superior retention even at high organic levels. Many LC-MS applications rely on high level of organic modifier in the mobile phase, particularly in the for high performance trace analysis requiring high sensitivity and low level detection

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Epic C18 MSO

Epic C18 MSO (mass spec optimized) is specifically engineered for the demands of LC-MS with or without the use of ultra-high pressure pumps. The flexibility of Epic C18-MSO is the result of our research into optimal particle diameters that can be used for both routine and ultra-high pressure pumping systems. Epic C18-MSO is based upon 2.3um fully porous particles giving it superior retention even at high organic levels while maintaining excellent sample loading.

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Epic C18 SD

Epic C18 SD sub-2 micron is specifically engineered for the demands of high performance HPLC. Epic C18-SD is a product of high bonding density technology; high bonding density provides the maximum stationary phase interaction providing a platform for flexible mobile phase compositions. It provides superior retention even at low and especially at high organic levels. In addition, it is compatible with all LC-MS mobile phases and buffer systems.

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Epic C30

Epic C30 is a highly base deactivated phase that produces the most inert silica C30 material available today. This column demonstrates superior peak shapes for the most demanding tests. Epic C30 provides exceptional peak shape and selectivity over a wide pH range (pH 1-12).

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Epic C4 SD

Epic C4 SD is a highly base deactivated high carbon super dense (SD) phase that is produced via a multiple step process. The first step involves the HD bonding of monomeric C4 reagent. The second step utilizes a proprietary multiple endcapping bonding process that produces highly base deactivated columns. The Epic C4 SD product, as a result of our special bonding treatment, is highly hydrophobic and exceptionally inert for the analysis of both acids and bases. With our super dense bonding this product also has a wide pH range (1-12)

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Epic C8

Epic C8 is a highly base deactivated phase that produces the most inert silica C8 material available today. Because of the high density bonding levels (4umol/m2) this column demonstrates superior peak shapes for the most demanding tests. Epic C8 provides exceptional peak shape and selectivity over a wide pH range (pH 1-12).

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Epic Cyano

The Epic bonding technology produces columns of superior performance and durability. These performance characteristics result from the high bonding density found in the Epic bonding process.

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Epic Diol

The Epic bonding technology produces columns of superior performance and durability. These performance characteristics result from the high bonding density found in the Epic bonding process.

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Epic Diol HILIC

Epic Diol HILIC 1.8 um columns have been specifically developed for HILIC chromatography. The combination of tight particle size control and our proprietary high density bonding technology deliver superior performance for HILIC separations.

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Epic Diphenyl

Epic Diphenyl bonded phase, with reduced hydrophobicity produces HPLC columns with novel selectivity, exhibiting increased speed and resolution, utilizes strong dipole‐dipole hydrogen bonding and π‐π mechanisms for different selectivity for compounds containing double bonds or aromatic functional groups. In addition, the diphenyl arrangement of the phase can also contribute to steric selectivity allowing for an additional chromatographic interaction. Epic Diphenyl is also highly selective for proteins with aromatic side chains and may be used as a USP L11 column.

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Epic FDD

The Epic bonding technology produces columns of superior performance and durability. These performance characteristics result from the high bonding density found in the Epic bonding process.

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Epic FO LB

A baseline stabilized alkyl perfluorinated C8 – Epic FO-LB, with low bleed characteristics is well suited to the separation of trace impurities especially for halogenated analytes, lipophilic compounds and environmental samples.

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Epic HILIC FL

Epic HILIC-FL is useful for retention and separation of polar and non-compounds. Reversed-phase HPLC is widely used for separation of many pharmaceutical compounds. However, retention and separation of many polar analytes has proven to be a challenge. Many of these types of compounds are unretained or poorly retained on most conventional reversed-phase stationary phases, such as ODS. Fortunately, to deal with these types of analytes an alternative mode of chromatography can be utilized using polar stationary phases and highly organic mobile phases. This mode of chromatography has been utilized for many years and is referred to as “hydrophilic interaction chromatography” or HILIC. HILIC chromatography uses mobile phases containing between 5 – 20 % water for the retention of polar compounds.

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Epic HILIC HC

Epic HILIC-HC (HC for high capacity) is a new stationary phase for HILIC chromatography. It is composed of a polyhydroxylated polymer coated and bound to silica. This composition provides hydroxyl levels that are well above conventional hydroxyl and diol type stationary phases. Many of the commercially stationary phases used for HILIC chromatography are converted normal phase columns. These normal phase columns yield poor methods, poor separations and lack durability. Epic HILIC-HC is specifically designed for HILIC chromatography and can achieve high performance separations, yield rugged methods and deliver long column life times.

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Epic HILIC PI

Epic HILIC-PI is a new stationary phase for HILIC chromatography. It consists of an aromatic amine based stationary phase bound to silica. This composition provides for excellent retention and peak shape for polar amine compounds. Many of the commercially available HILIC stationary phases are converted normal phase columns. These normal phase columns yield poor methods, poor separations and lack durability. Epic HILIC-PI is specifically designed for HILIC chromatography and can achieve high performance separations, yield rugged methods and deliver long column life times. Epic HILIC-PI is an excellent choice for samples containing polar amines were superior retention and peak shape are essential.

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Epic HILIC POH

Epic HILIC-POH a polyhydroxylated material specifically designed for HILIC chromatography that can achieve high performance separations, yield rugged methods and deliver long column life times and is useful for the retention and separation of polar and nonpolar compounds. This composition provides hydroxyl levels that are uniform, reproducible and well above conventional hydroxyl and diol type stationary phases.

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Epic HILIC RP

Epic HILIC-RP is a new stationary phase for a combination of HILIC and reverse phase chromatography. It is a combination of a polyhydroxylated polymer coated and bound to silica and ODS groups also bound to silica. This composition provides hydroxyl levels that are well above conventional hydroxyl and diol type stationary phases. Many of the commercially stationary phases used for HILIC chromatography are converted normal phase columns. These normal phase columns yield poor methods, poor separations and lack durability. Epic HILIC-RP is specifically designed for HILIC chromatography and can achieve high performance separations, yield rugged methods and deliver long column life times. Epic HILIC-RP is an excellent choice for samples containing polar and hydrophobic analytes.

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Epic HILIC Silica

Epic HILIC Silica 1.8 um columns have been specifically developed for HILIC chromatography. The combination of tight particle size control and high specific surface area deliver superior performance for HILIC separations.

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Epic Naphthyl

Epic Naphthyl is a naphthalene based material, with high bonding density and intrinsic base deactivation due to a rigid structure that also enables the shape selectivity needed for many diastereomeric separations. It exhibits strong π-π interaction and charge transfer interactions and performs well for diastereomers separations and non-polar compounds. The unique properties of Epic Naphthyl places its selectivity between graphitized carbon and alkyl type stationary phases.

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Epic PFP LB

The Epic PFP-LB is a pentafluorophenyl that has been baseline stabilized and is ready for high performance separations for a number of applications including the separation of natural products, halogenated compounds, aromatics, conjugated compounds and trace impurities in complex matrices. Many of these high performance separations were not possible with existing PFP columns especially in the area of trace impurities where baseline bleed levels were unacceptable.

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