MacroDac™ is an excellent alternative to W.R. Grace VYDAC® wide pore C18 chromatography media. MacroDac™ C18 is the ideal medium for high- performance reversed-phase chromatography of proteins, peptides, and other large molecules that had previously been difficult to separate by reversed-phase HPLC procedures. The large pores of the 300Å silica allow polypeptide molecules complete access to the interior of the silica pores.