Products

Regis Technologies Chiral Columns

Pirkle-type Chiral Columns

In 1980, Regis Technologies along with Professor William Pirkle of the University of Illinois, introduced the Pirkle Chiral Stationary Phase (CSP). Today ES Industries sells nine Pirkle CSPs in analytical and preparative sizes and in bulk material.

a-Burke

Analytical and Semi-Preparative Columns

The α-Burke 2 phase is derived from dimethyl N-3,5-dinitro-benzoyl--amino-2,2-dimethyl- 4-pentenyl phosphonate covalently bound to 5 µm silica. This π-acceptor chiral stationary phase is particularly valuable in the HPLC separation of β-blocker enantiomers, an important class of cardiovascular drugs whose enantiomers often exhibit differing pharmacological activities. The α-Burke 2 has been specifically designed to separate the enantiomers of β-blockers without chemical derivatization. In addition, it also resolves the enantiomers of many compounds separated on π-acceptor Pirkle type chiral stationary phases.

Spherical Silica

Phase Code Particle Size Column Dimensions Part Number Add
(R)-a-BurkeÁ 2 5 µm, 100 Á 25 cm x 10.0 mm i.d. 735235
(R)-a-Burke 2 5 µm, 100 Á 25 cm x 21.1 mm i.d. 735236
(R)-a-Burke 2 5 µm, 100 Á 25 cm x 4.6 mm i.d. 735035
(S)-a-Burke 2 5 µm, 100 Á 25 cm x 10.0 mm i.d. 735237
(S)-a-Burke 2 5 µm, 100 Á 25 cm x 21.1 mm i.d. 735238
(S)-a-Burke 2 5 µm, 100 Á 25 cm x 4.6 mm i.d. 735037

ß-Gem 1

Analytical and Semi-Preparative Columns

ß-Gem1is a π-acceptor chiral stationary phase and is prepared by covalently bonding N-3, 5-dinitrobenzoyl-3-amino- 3-phenyl-2-(1,1-dimethylethyl)-propanoate, to 5 µm silica through an ester linkage. In many cases, this chiral phase considerably outperforms its widely used analog, phenylglycine. It can separate anilide derivatives of chiral carboxylic acids, including nonsteroidal anti-inflammatory agents.

Spherical Silica

Phase Code Particle Size Column Dimensions Part Number Add
(R,R)- ß-GEM 1 5 µm, 100 Á 25 cm x 10.0 mm i.d. 731243
(R,R)- ß-GEM 1 5 µm, 100 Á 25 cm x 21.1 mm i.d. 731343
(R,R)- ß-GEM 1 5 µm, 100 Á 25 cm x 4.6 mm i.d. 731043
(S,S)- ß-GEM 1 5 µm, 100 Á 25 cm x 10.0 mm i.d. 731229
(S,S)- ß-GEM 1 5 µm, 100 Á 25 cm x 21.1 mm i.d. 731329
(S,S)- ß-GEM 1 5 µm, 100 Á 25 cm x 4.6 mm i.d. 731029

DACH-DNB

Analytical to Preparative Columns

The innovative DACH-DNB CSP was designed by Italian chemist, Professor Francesco Gasparrini, at Rome University La Sapienza. The DACH-DNB CSP, which contains the 3,5-dinitrobenzoyl derivative of 1,2-diaminocyclohexane, has been found to resolve a broad range of racemate classes including amides, alcohols, esters, ketones, acids, sulfoxides, phosphine oxides, selenoxides, phosphonates, thiophosphineoxide, phosphineselenide, phosphine-borane, beta-lactams, organometallics, atropisomers and heterocycles.

Spherical Silica

Phase Code Particle Size Column Dimensions Part Number Add
(R,R)-DACH-DNB 5 µm, 100 Å 25 cm x 10.0 mm i.d. 788102
(R,R)-DACH-DNB 5 µm, 100 Å 25 cm x 30.0 mm i.d. 788104
(R,R)-DACH-DNB 5 µm, 100 Å 25 cm x 4.6 mm i.d. 788101
(S,S)-DACH-DNB 5 µm, 100 Å 25 cm x 10.0 mm i.d. 788202
(S,S)-DACH-DNB 5 µm, 100 Å 25 cm x 30.0 mm i.d. 788204
(S,S)-DACH-DNB 5 µm, 100 Å 25 cm x 4.6 mm i.d. 788201

Spherical Kromasil® Silica

Phase Code Particle Size Column Dimensions Part Number Add
(R,R)-DACH-DNB 10 µm, 100 Å 25 cm x 21.1 mm i.d. 788103
(R,R)-DACH-DNB 10 µm, 100 Å 25 cm x 30.0 mm i.d. 788707
(R,R)-DACH-DNB 10 µm, 100 Å 25 cm x 4.6 mm i.d. 788401
(R,R)-DACH-DNB 10 µm, 100 Å 25 cm x 50.0 mm i.d. 788708
(R,R)-DACH-DNB 10 µm, 100 Å 50 cm x 30.0 mm i.d. 788712
(R,R)-DACH-DNB 10 µm, 100 Å 50 cm x 50.0 mm i.d. 788709
(S,S)-DACH-DNB 10 µm, 100 Å 25 cm x 10.0 mm i.d. 788302
(S,S)-DACH-DNB 10 µm, 100 Å 25 cm x 21.1 mm i.d. 788203
(S,S)-DACH-DNB 10 µm, 100 Å 25 cm x 30.0 mm i.d. 788701
(S,S)-DACH-DNB 10 µm, 100 Å 25 cm x 4.6 mm i.d. 788301
(S,S)-DACH-DNB 10 µm, 100 Å 25 cm x 50.0 mm i.d. 788702
(S,S)-DACH-DNB 10 µm, 100 Å 50 cm x 30.0 mm i.d. 788715
(S,S)-DACH-DNB 10 µm, 100 Å 50 cm x 50.0 mm i.d. 788705

Leucine

Analytical and Semi-Preparative Columns

The π-acceptor leucine CSP is based on 3,5-dinitrobenzoyl leucine, covalently bonded to 5 µm aminopropyl silica. Columns derived from either L- or D- leucine are available. This phase demonstrates enhanced enantioselectivities for several classes of compounds, including benzodiazapines.

Spherical Silica

Phase Code Particle Size Column Dimensions Part Number Add
D-Leucine 5 µm, 100 Á 25 cm x 10.0 mm i.d. 731254
D-Leucine 5 µm, 100 Á 25 cm x 21.1 mm i.d. 731354
D-Leucine 5 µm, 100 Á 25 cm x 4.6 mm i.d. 731054
L-Leucine 5 µm, 100 Á 25 cm x 10.0 mm i.d. 731241
L-Leucine 5 µm, 100 Á 25 cm x 21.1 mm i.d. 731341
L-Leucine 5 µm, 100 Á 25 cm x 4.6 mm i.d. 731041

Phenylglycine

Analytical and Semi-Preparative Columns

Phenylglycine, a π-acceptor chiral phase, is based on 3,5-dinitrobenzoyl phenylglycine, covalently bonded to 5 µm aminopropyl silica. Phenylglycine columns are available in both L- and D- configurations. This CSP resolves a wide variety of compounds containing π-basic groups, including: aryl-substituted cyclic sulfoxides, bi-β-naphthol and its analogs, α-indanol and α-tetralol analogs, and aryl-substituted hydantoins.

Spherical Silica

Phase Code Particle Size Column Dimensions Part Number Add
D-Phenylglycine 5 µm, 100 Á 25 cm x 10.0 mm i.d. 731221
D-Phenylglycine 5 µm, 100 Á 25 cm x 21.1 mm i.d. 731331
D-Phenylglycine 5 µm, 100 Á 25 cm x 4.6 mm i.d. 731021
L-Phenylglycine 5 µm, 100 Á 25 cm x 10.0 mm i.d. 731224
L-Phenylglycine 5 µm, 100 Á 25 cm x 21.1 mm i.d. 731334
L-Phenylglycine 5 µm, 100 Á 25 cm x 4.6 mm i.d. 731024

Pirkle 1-J

Analytical and Preparative Columns

The Pirkle 1-J column is the latest in a series of CSPs from the research laboratories of Professor Pirkle. This new CSP contains an unusual β-lactam structure which significantly alters its molecular recognition properties. The Pirkle 1-J is useful for the direct separation of underivatized β-blocker enantiomers.
It can also be used for the separation of the enantiomers of arylpropionic acid NSAIDs, as well as other drugs.

Spherical Silica

Phase Code Particle Size Column Dimensions Part Number Add
(3R,4S)-Pirkle 1-J 5 µm, 100 Á 25 cm x 10.0 mm i.d. 731244
(3R,4S)-Pirkle 1-J 5 µm, 100 Á 25 cm x 21.1 mm i.d. 731344
(3R,4S)-Pirkle 1-J 5 µm, 100 Á 25 cm x 4.6 mm i.d. 731044
(3S,4R)-Pirkle 1-J 5 µm, 100 Á 25 cm x 10.0 mm i.d. 731245
(3S,4R)-Pirkle 1-J 5 µm, 100 Á 25 cm x 21.1 mm i.d. 731345
(3S,4R)-Pirkle 1-J 5 µm, 100 Á 25 cm x 4.6 mm i.d. 731045

ULMO

Analytical and Semi-Preparative Columns

The ULMO chiral stationary phase was developed by Austrian researchers Dr. Georg Uray, Dr. Wolfgang Linder and Dr. Nobert Maier. The ULMO CSP is based on a 3,5-dintrobenzoyl derivative of diphenylethylenediamine. This CSP has a general ability to separate the enantiomers of many racemate classes and is particularly good at separating the enantiomers of aryl carbinols.

Spherical Silica

Phase Code Particle Size Column Dimensions Part Number Add
(R,R)-ULMO 5 µm, 100 Á 25 cm x 10.0 mm i.d. 787201
(R,R)-ULMO 5 µm, 100 Á 25 cm x 30.0 mm i.d. 787203
(R,R)-ULMO 5 µm, 100 Á 25 cm x 4.6 mm i.d. 787200
(S,S)-ULMO 5 µm, 100 Á 25 cm x 10.0 mm i.d. 787101
(S,S)-ULMO 5 µm, 100 Á 25 cm x 30.0 mm i.d. 787103
(S,S)-ULMO 5 µm, 100 Á 25 cm x 4.6 mm i.d. 787100

Spherical Kromasil® Silica

Phase Code Particle Size Column Dimensions Part Number Add
(R,R)-ULMO 10 µm, 100 Á 25 cm x 10.0 mm i.d. 787401
(R,R)-ULMO 10 µm, 100 Á 25 cm x 21.1 mm i.d. 787202
(R,R)-ULMO 10 µm, 100 Á 25 cm x 30.0 mm i.d. 787707
(R,R)-ULMO 10 µm, 100 Á 25 cm x 4.6 mm i.d. 787400
(R,R)-ULMO 10 µm, 100 Á 25 cm x 50.0 mm i.d. 787708
(R,R)-ULMO 10 µm, 100 Á 50 cm x 30.0 mm i.d. 787712
(R,R)-ULMO 10 µm, 100 Á 50 cm x 50.0 mm i.d. 787709
(S,S)-ULMO 10 µm, 100 Á 25 cm x 10.0 mm i.d. 787301
(S,S)-ULMO 10 µm, 100 Á 25 cm x 21.1 mm i.d. 787102
(S,S)-ULMO 10 µm, 100 Á 25 cm x 30.0 mm i.d. 787701
(S,S)-ULMO 10 µm, 100 Á 25 cm x 4.6 mm i.d. 787300
(S,S)-ULMO 10 µm, 100 Á 25 cm x 50.0 mm i.d. 787702
(S,S)-ULMO 10 µm, 100 Á 50 cm x 30.0 mm i.d. 787715
(S,S)-ULMO 10 µm, 100 Á 50 cm x 50.0 mm i.d. 787703

Whelk-O®1

Analytical to Preparative Columns

The Whelk-O 1 is useful for the separation of underivatized enantiomers in a number of families including amides, epoxides, esters, ureas, carbamates, ethers, aziridines, phosphonates, aldehydes, ketones, carboxylic acids, alcohols and non-steroidal anti-inflammatory drugs (NSAIDs). This π-electron acceptor/π-electron donor phase exhibits an extraordinary degree of generality. The broad versatility observed on the Whelk-O 1 column compares favorably with polysaccharidederived chiral stationary phases.
In addition, because Whelk-O 1 is covalently bonded to the support, the phase is compatible with all commonly used mobile phases, including aqueous systems — a distinct advantage over polysaccharide derived chiral stationary phases. Other advantages include column durability, excellent efficiency, ability to invert elution order and excellent preparative capacity

Spherical Silica

Phase Code Particle Size Column Dimensions Part Number Add
(R,R)-Whelk-O 1 5 µm, 100Á 25 cm x 10.0 mm i.d. 786202
(R,R)-Whelk-O 1 5 µm, 100Á 25 cm x 30.0 mm i.d. 786205
(R,R)-Whelk-O 1 5 µm, 100Á 25 cm x 4.6 mm i.d. 786201
(S,S)-Whelk-O 1 5 µm, 100Á 25 cm x 10.0 mm i.d. 786102
(S,S)-Whelk-O 1 5 µm, 100Á 25 cm x 30.0 mm i.d. 786105
(S,S)-Whelk-O 1 5 µm, 100Á 25 cm x 4.6 mm i.d. 786101

Spherical Kromasil® Silica

Phase Code Particle Size Column Dimensions Part Number Add
(R,R)-Whelk-O 1 10 µm, 100Á 25 cm x 10.0 mm i.d. 786525
(R,R)-Whelk-O 1 10 µm, 100Á 25 cm x 21.1 mm i.d. 786535
(R,R)-Whelk-O 1 10 µm, 100Á 25 cm x 30.0 mm i.d. 786708
(R,R)-Whelk-O 1 10 µm, 100Á 25 cm x 4.6 mm i.d. 786515
(R,R)-Whelk-O 1 10 µm, 100Á 25 cm x 50.0 mm i.d. 786709
(R,R)-Whelk-O 1 10 µm, 100Á 50 cm x 21.1 mm i.d. 786545
(R,R)-Whelk-O 1 10 µm, 100Á 50 cm x 30.0 mm i.d. 786713
(R,R)-Whelk-O 1 10 µm, 100Á 50 cm x 50.0 mm i.d. 786710
(R,R)-Whelk-O 1 5 µm, 100Á 25 cm x 10.0 mm i.d. 780202
(R,R)-Whelk-O 1 5 µm, 100Á 25 cm x 30.0 mm i.d. 780203
(R,R)-Whelk-O 1 5 µm, 100Á 25 cm x 4.6 mm i.d. 780201
(R,R)-Whelk-O 1 5 µm, 100Á 25 cm x 50.0 mm i.d. 780204
(S,S)-Whelk-O 1 10 µm, 100Á 25 cm x 10.0 mm i.d. 786625
(S,S)-Whelk-O 1 10 µm, 100Á 25 cm x 21.1 mm i.d. 786635
(S,S)-Whelk-O 1 10 µm, 100Á 25 cm x 30.0 mm i.d. 786702
(S,S)-Whelk-O 1 10 µm, 100Á 25 cm x 4.6 mm i.d. 786615
(S,S)-Whelk-O 1 10 µm, 100Á 25 cm x 50.0 mm i.d. 786703
(S,S)-Whelk-O 1 10 µm, 100Á 50 cm x 21.1 mm i.d. 786645
(S,S)-Whelk-O 1 10 µm, 100Á 50 cm x 30.0 mm i.d. 786716
(S,S)-Whelk-O 1 10 µm, 100Á 50 cm x 50.0 mm i.d. 786704
(S,S)-Whelk-O 1 5 µm, 100Á 25 cm x 10.0 mm i.d. 780102
(S,S)-Whelk-O 1 5 µm, 100Á 25 cm x 30.0 mm i.d. 780103
(S,S)-Whelk-O 1 5 µm, 100Á 25 cm x 4.6 mm i.d. 780101
(S,S)-Whelk-O 1 5 µm, 100Á 25 cm x 50.0 mm i.d. 780104

Whelk-O®2

Analytical to Preparative Columns

Our newest addition to the Whelk-O line of chiral stationary phases is the Whelk-O 2. The Whelk-O 2 is the covalent trifunctional version of the Whelk-O 1. The Whelk-O 2 retains the same chiral selector but incorporates a trifunctional linkage to the silica support. In most cases, the enantioselectivity remains the same as that obtained with the Whelk-O 1. Whelk-O 2 was designed to improve the resistance of the stationary phase to hydrolysis while using strong organic modifiers such as trifluoroacetic acid. The Whelk-O 2 is ideal for preparative separations since the material is bonded on 10 µm, 100Å spherical Kromasil silica. This allows the preparative chromatographer to perform method development on an analytical column and immediately scale up to larger diameter columns.

Spherical Kromasil® Silica

Phase Code Particle Size Column Dimensions Part Number Add
(R,R)-Whelk-O 2 10 µm, 100Á 25 cm x 10.0 mm i.d. 786325
(R,R)-Whelk-O 2 10 µm, 100Á 25 cm x 21.1 mm i.d. 786335
(R,R)-Whelk-O 2 10 µm, 100Á 25 cm x 30.0 mm i.d. 786727
(R,R)-Whelk-O 2 10 µm, 100Á 25 cm x 4.6 mm i.d. 786315
(R,R)-Whelk-O 2 10 µm, 100Á 25 cm x 50.0 mm i.d. 786728
(R,R)-Whelk-O 2 10 µm, 100Á 50 cm x 21.1 mm i.d. 786345
(R,R)-Whelk-O 2 10 µm, 100Á 50 cm x 30.0 mm i.d. 786732
(R,R)-Whelk-O 2 10 µm, 100Á 50 cm x 50.0 mm i.d. 786729
(S,S)-Whelk-O 2 10 µm, 100Á 25 cm x 10.0 mm i.d. 786425
(S,S)-Whelk-O 2 10 µm, 100Á 25 cm x 21.1 mm i.d. 786435
(S,S)-Whelk-O 2 10 µm, 100Á 25 cm x 30.0 mm i.d. 786721
(S,S)-Whelk-O 2 10 µm, 100Á 25 cm x 4.6 mm i.d. 786415
(S,S)-Whelk-O 2 10 µm, 100Á 25 cm x 50.0 mm i.d. 786722
(S,S)-Whelk-O 2 10 µm, 100Á 50 cm x 21.1 mm i.d. 786445
(S,S)-Whelk-O 2 10 µm, 100Á 50 cm x 30.0 mm i.d. 786736
(S,S)-Whelk-O 2 10 µm, 100Á 50 cm x 50.0 mm i.d. 786723



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