Chromegabond NPI is a polar bonded column for normal phase chromatography. This new phase is produced by bonding a monoalcohol to ultra-high purity silica. This phase provides similar selectivity to silica gel but is considerably less active. Relative to analysis using silica gel, peak shapes are greatly improved and irreversible adsorption is minimal. The selectivity is similar to coated polyvinyl alcohol packings, however, unlike these coated packings the NPI chemistry can be bonded to large diameter particles for preparative columns. The Chromegabond NPI column also exhibits different selectivity other than polar bonded columns such as diol and cyano. An NPI column is very useful for separation and isolation of compounds found in natural products. In addition, it is useful in the separation of steroids and fat-soluble vitamins.
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