Chromegabond FSP is a truly unique stationary phase with properties significantly different than ODS phases. This unique character results from bonded pentafluorophenyl groups imparting a pi-pi electron interaction which produces an enhanced retention for many compounds particularly those that contain polarizable electrons. Many classes of compounds contain polarizable electrons including halogenated compounds, aromatics, and conjugated systems. Many naturally occurring chemicals also contain polarizable electrons and can be separated using Chromegabond FSP. Chromegabond FSP has been extremely useful in the separation of epimers. Epimers also exist in many natural mixtures such as pharmaceutically active natural taxol. Chromegabond FSP is an excellent alternative to ODS Columns for the bulk characterization of pharmaceuticals. It can be a difficult task to uncover an impurity profile for a bulk pharmaceutical substance. Many of the impurities co-elute with the active compound on ODS columns and even major changes in mobile phase composition can fail to effect a separation. Chromegabond FSP because of its unique separation mechanism can often separate these impurities. In addition, impurities can be more definitively resolved thus improving quantification and reproducibility.
Traditionally columns that rely on selective mechanisms for separations have had a poor track record of consistent performance. Variations in component retention times, peak resolution factors, and elution profiles are unacceptable. These variations have rendered selective columns suspect and relegated them to a secondary role behind ODS columns. At ES Industries we are confident that we have established reliable chemical bonding procedures utilizing the finest ultra-high pure silica available and a tightly controlled manufacturing process to deliver Chromegabond FSP columns that surpass the ruggedness, reliability, and reproducibility of any ODS type column available commercially. Production of Chromegabond FSP columns are carefully monitored with a quality control program specifically tailored to its unique retention properties. The typical QC tests applied to ODS type columns are inadequate when applied to the super selective FSP columns. These tests simply rely on hydrophobic interactions making them insensitive to other retention mechanisms. At ES Industries we have developed specific criteria that utilize special test probes which are sensitive to pi-pi interactions and guarantee consistent separations.
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